Association of miRNA-492 rs2289030 G>C and miRNA-938 rs2505901 T>C Gene Polymorphisms with Biliary Atresia Susceptibility

• 作者: SU Liang TIAN Yan FU Ming ZHANG Rui Zhong OU Xiu Fei XIA Hui Min LI Rui Zhuo
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 577-580,中插31
• 页数: 5页
• 语种: 英文
• DOI: 10.3967/bes2021.080

摘要

Biliary atresia (BA) is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis, which occurs in 1 in 8,000 to 1 in 18,000 live births[1]. Revealing of the mechanisms underlying BA is crucial for early diagnosis, intervention, and better prognosis. The etiology of BA remains unclear, and currently, noncoding and epigenetic factors, rather than classic genetic alterations, are assumed to be responsible for genetic predisposition to BA.