Ferroptosis,radiotherapy,and combination therapeutic strategies

• 作者: Guang Lei Chao Mao Yuelong Yan Li Zhuang Boyi Gan
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（11）
• 所属期刊栏目: REVIEW
• 页码范围: 836-857
• 页数: 22页
• 语种: 英文

摘要

Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid-containing phospholipids in cellular membranes,has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression,and to mediate the synergy between radiotherapy and immunotherapy.In this review,we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and fer-roptosis,discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy,and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy.This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.