Synthesis,Crystal Structure and Insecticidal Activities of(4aR,7aS)-6-Benzyl-1-((R)-2-(2-chlorophenyl)-4,5-dihydrothiazole-4-carbonyl)hexahydro-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione

• 作者: LIU Jing-Bo QIN Na WANG Yuan-Hong LI Yu-Xin LI Zheng-Ming
• 来源期刊: 结构化学
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: medicinal structural chemistry
• 页码范围: 659-665
• 页数: 7页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2974

摘要

The title compound(4aR,7aS)-6-benzyl-1-((R)-2-(2-chlorophenyl)-4,5-dihydrothiazole-4-carbonyl)-hexahydro-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione(C24H22ClN3O3S)was synthesized,and its chemical structure was confirmed by 1H NMR,13C NMR and single-crystal X-ray diffraction.The crystal of the title compound belongs to monoclinic system,space group C2/c with a = 28.929(6),b = 7.858(16),c = 22.936(5)?,β = 125.20(3)°,V = 4221.4(15)?3,Z=8,Dc = 1.473 g/cm3,μ(MoKa)= 0.314 mm-1,the final R = 0.0629 and wR = 0.1708 for 2812 observed reflections with I＞2σ(I).The preliminary insecticidal activity indicated that the title compound exhibited good and promising insecticidal activities against Mythimna separata,Plutella xylostella and C u lex pipiens pallens.Moreover,the calcium imaging experiment indicated that the title compound can activate intracellular calcium channels to release the stored calcium ion from endoplasmic reticulum(ER)to cytoplasm of Mythimna separata.