Manganese nanodepot augments host immune response against coronavirus

• 作者: Yizhe Sun Yue Yin Lidong Gong Zichao Liang Chuanda Zhu Caixia Ren Nan Zheng Qiang Zhang Haibin Liu Wei Liu Fuping You Dan Lu Zhiqiang Lin
• 来源期刊: 纳米研究（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Research Articles
• 页码范围: 1260-1272
• 页数: 13页
• 语种: 英文

摘要

Interferon (IFN) responses are central to host defense against coronavirus and other virus infections.Manganese (Mn) is capable of inducing IFN production,but its applications are limited by nonspecific distributions and neurotoxicity.Here,we exploit chemical engineering strategy to fabricate a nanodepot of manganese (nanoMn) based on Mn2+.Compared with free Mn2+,nanoMn enhances cellular uptake and persistent release of Mn2+ in a pH-sensitive manner,thus strengthening IFN response and eliciting broad-spectrum antiviral effects in vitro and in vivo.Preferentially phagocytosed by macrophages,nanoMn promotes M1 macrophage polarization and recruits monocytes into inflammatory foci,eventually augmenting antiviral immunity and ameliorating coronavirus-induced tissue damage.Besides,nanoMn can also potentiate the development of virus-specific memory T cells and host adaptive immunity through facilitating antigen presentation,suggesting its potential as a vaccine adjuvant.Pharmacokinetic and safety evaluations uncover that nanoMn treatment hardly induces neuroinflammation through limiting neuronal accumulation of manganese.Therefore,nanoMn offers a simple,safe,and robust nanoparticle-based strategy against coronavirus.