Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3-Naphthylated Indoles from β-Alkynyl Ketones and o-Alkynyl Anilines

• 作者: Dan Wang Shi-Chao Wang Wen-Juan Hao Shu-Jiang Tu Bo Jiang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 106-114
• 页数: 9页
• 语种: 英文
• DOI: 10.1002/cjoc.202000304

摘要

A new dual palladium/scandium catalysis starting from β-alkynyl ketones and o-alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in moderate to good yields and high regioselectivi-ty.This method can tolerate normal air conditions,and features the use of palladium/scandium cooperative catalysts without any ligand,facile double annulation involving various internal alkynes,and good functional group tolerance.