Dual factors of climate and human on the hydrological process are reflected not only in changes in the spatiotemporal distribution of water resource amounts but also in the various characteristics of river flow regimes.Isolating and quantifying their contributions to these hydrological alterations helps us to comprehensively understand the response mecha-nism and patterns of hydrological process to the two kinds of factors.Here we develop a general framework using hydrological model and 33 indicators to describe hydrological pro-cess and quantify the impact from climate and human.And we select the Upper Minjiang River (UMR) as a case to explore its feasibility.The results indicate that our approach suc-cessfully recognizes the characteristics of river flow regimes in different scenarios and quan-titatively separates the climate and human contributions to multi-dimensional hydrological alterations.Among these indicators,26 of 33 indicators decrease over the past half-century(1961-2012) in the UMR,with change rates ranging from 1.3% to 33.2%,and the human impacts are the dominant factor affecting hydrological processes,with an average relative contribution rate of 58.6%.Climate change causes an increase in most indicators,with an average relative contribution rate of 41.4%.Specifically,changes in precipitation and reservoir operation may play a considerable role in inducing these alterations.The findings in this study help us better understand the response mechanism of hydrological process under changing environment and is conducive to climate change adaptation,water resource planning and ecological construction.