Biological drug and drug delivery-mediated immunotherapy

• 作者: Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Reviews
• 页码范围: 941-960
• 页数: 20页
• 语种: 英文

摘要

The initiation and development of major inflammatory diseases,i.e.,cancer,vascular inflam-mation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immu-notherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major inflammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this field.