Sarcaglarols A-D,Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks

• 作者: Yongyue Wang Zhirong Cui Jun Chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 129-136
• 页数: 8页
• 语种: 英文
• DOI: 10.1002/cjoc.202000456

摘要

Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based strategy.Their planar structures,abso-lute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene derivatives.An intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene conjugates.In addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells.