Ultrasensitive antigen density discrimination by synNotch

• 作者: Divanshu Shukla James L.Riley
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 725-726
• 页数: 2页
• 语种: 英文

摘要

In a recent study published in Science,Hernandez-Lopez et al.engineered a low-to-high two-step regulatory circuit that allows T cells to discriminate target antigens with an ultrasensitive threshold.In this circuit,low-affinity synNotch receptor controls the expression of the high-affinity chimeric antigen receptor (CAR);thus,the only time the CAR construct is expressed is in the presence of high levels of antigen,preventing off-tumor CAR T cell recognition.