The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems

• 作者: Canyu Yang Bing He Wenbing Dai Hua Zhang Ying Zheng Xueqing Wang Qiang Zhang
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Reviews
• 页码范围: 961-977
• 页数: 17页
• 语种: 英文

摘要

As one of the most important components of caveolae,caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways,and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction.In recent years,the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treat-ment and drug treatment resistance has also been widely explored.In addition,the interplay between caveolin-1 and nano-drugs is bidirectional.Caveolin-1 could determine the intracellular biofate of spe-cific nano-drugs,preventing from lysosomal degradation,and facilitate them penetrate into deeper site of tumors by transcytosis;while some nanocarriers could also affect caveolin-1 levels in tumor cells,thereby changing certain biophysical function of cells.This article reviews the role of caveolin-1 in tumor prognosis,chemotherapeutic drug resistance,antibody drug sensitivity,and nano-drug delivery,providing a reference for the further application of caveolin-1 in nano-drug delivery systems.