Syntheses, Crystal Structures and Inhibitory Activity against MCF-7, NCI-H460 and HepG2 Cancer Cells of the Di-2,4-dichlorobenzyltin Thiophene-2-carbohydrazone Complexes

• 作者: XU Jia-Chi HU Ze-Cheng CUI Ying JIANG Wu-Jiu TAN Yu-Xing FAN Shan-Ji
• 来源期刊: 结构化学
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: medicinal structural chemistry
• 页码范围: 827-835
• 页数: 9页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-3007

摘要

Di-2,4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-propanoic carboxylate complex I {[C4H3S(O)C=N-N=C(CH3)COO]2[(2,4-Cl2-C6H3CH2)2Sn]2(CH3OH)2} and di-2,4-dichlorobenzyltin-2-(2-(thio- phen-2-formyl)hydrazono)-3-phenylpropanoic carboxylate complex Ⅱ{[C4H3S(O)C=N-N=C(PhCH2)COO](2,4- Cl2-C6H3CH2)2Sn}n were synthesized and characterized by IR, 1H, 13C and 119Sn NMR spectra, HRMS, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex I belongs to monoclinic system, space group P21/n with a = 11.987(3), b = 35.359(9), c = 12.982(3) ?, β = 103.028(5)°, Z = 4, V = 5361(2) ?3, Dc = 1. 688 Mg·m–3, μ(MoKα) = 1.463 mm–1, F(000) = 2704, R = 0.0572 and wR = 0.1423. The crystal of complex Ⅱ is of monoclinic system, space group P21/n with a = 15.5758(17), b = 9.6020(10), c = 19.599(2) ?, β = 98.886(2)°, Z = 4, V = 2896.0(5) ?3, Dc = 1.663 Mg·m–3, μ(MoKα) = 1.357 mm–1, F(000) = 1440, R = 0.0341 and wR = 0.0936. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (MCF7, NCI-H460 and HepG2), and they all exhibited good antitumor activity. The interaction between complexes and calf thymus DNA was studied by UV-vis and fluorescence spectroscopy, it indicated intercalation as probable mode of interaction.