Remote light-activation of native Orai channels

• 作者: Sarah A.Kazzaz James H.Baraniak Jr Yandong Zhou Donald L.Gill
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 727-729
• 页数: 3页
• 语种: 英文

摘要

Optogenetic control of the Ca2+ signaling machinery has been a powerful approach but requires complex cell manipulation to introduce modified genes.A newly devel-oped non-invasive,ultrafast laser technique allows for the remote activation of native Orai1 Ca2+ channels,without the need for gene introduction,protein expression,or exogen-ous reagents.