A Brain-Spleen Axis Regulates Humoral Immunity

• 作者: Bin Zhang Jinjie Zhong Zhihua Gao
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Research Highlights
• 页码范围: 427-429
• 页数: 3页
• 语种: 英文

摘要

A happy mood helps to build a flourishing immune system.Interactions between the nervous and immune systems have attracted the interest of researchers for decades.It is well known that external stressors can activate the hypothalamus to regulate immune responses via the hypothalamic-pituitary-adrenal cortex (HPA) axis [1].As well, inflammatory stimuli can activate a rapid antiinflammatory reflex via the cholinergic vagus nerve pathway.An important target for the nervous systemelicited immune regulation is the spleen, a key organ where immune cells meet pathogens and antigens to trigger innateand adaptive immune responses.