A Risk Prediction Model for Ischemic Stroke in Southern Chinese Population: Impact of Multiple Genetic Variants and Clinical/Lifestyle Factors

• 作者: YE Cheng Yin LI Jin Mei WU Jing Hua LI Zheng XIAO Juan YIN Xiao Yu WANG Da Hui XU Guo Zhang YANG Lei
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 641-645,中插6-中插12
• 页数: 1页
• 语种: 英文
• DOI: 10.3967/bes2021.089

摘要

With a global prevalence of 7.7 million, ischemic stroke (IS) is one of the leading causes of death and disability worldwide. In China, IS alone contributed to 69.6％? of stroke events and accounted for 37.1％? of the mortality/disability rate[1]. IS is a complex disease that is known to be associated?with?various?genetic?variants?and?clinical and lifestyle risk factors[2]. Genome -wide association studies (GWAS) provided evidence for the?occurrence?of?more?than?160?IS-associated?single nucleotide?polymorphisms?(SNPs).?In?terms?of?clinical risk factors, patients with a history of chronic diseases like hypertension, dyslipidemia, and diabetes mellitus, display a higher risk of developing IS. Among the various lifestyle components, leading a sedentary lifestyle, smoking, and having an unhealthy diet are known to be associated with the risk of IS. Thus, integration of various genetic, clinical, and lifestyle variables might prove to be highly beneficial in the prediction and prevention of IS?at?the?individual?level[3].