Targeting PTB as a One-Step Procedure for In Situ Astrocyte-to-Dopamine Neuron Reprogramming in Parkinson's Disease

• 作者: Yuanyuan Jiang Yongjie Wang Zhihui Huang
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Research Highlights
• 页码范围: 430-432
• 页数: 3页
• 语种: 英文

摘要

Parkinson disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopamine neurons in the substantia nigra, resulting in striatal dopamine deficiency, hence eventually severe disability [1].Research carried out across the ＞200-year history of PD has led to important discoveries [2].Among them, efforts have been made to repair or promote regeneration using drugs, neurotrophic factors, cell-based disease modification, and cell replacement therapies in which exogenous cells are transplanted for functional improvement in neurodegenerative disorders.However, these treatment approaches are not sufficiently effective, while in recent years, the in situ repair strategy by trans-differentiation of certain somatic cells into functional neurons has gained great promise for the treatment of neurodegenerative diseases that feature loss of neurons [3].