Comparison of modified injection molding and conventional machining in biodegradable behavior of perforated cannulated magnesium hip stents

• 作者: Haiyue Zu Kelvin Chau Temitope Olumide Olugbade Lulu Pan Chris Halling Dreyer Dick Ho-Kiu Chow Le Huang Lizhen Zheng Wenxue Tong Xu Li Ziyi Chen Xuan He Ri Zhang Jie Mi Ye Li Bingyang Dai Jiali Wang Jiankun Xu Kevin Liu Jian Lu Ling Qin
• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2021,（4）
• 页码范围: 145-160
• 页数: 16页
• 语种: 英文

摘要

In this study,perforated cannulated magnesium (Mg) hip stents were fabricated via modified Mg injection molding and conventional machining,respectively.Additionally,the stent canal was filled with paraffin to simulate injection of biomaterials.The microstructure,mechanical performance,corrosion behavior,and biocompatibility were comparably studied.Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) showed higher affinity of interstitial element such as oxygen and carbon as consequences of routine molding process.After immersion in SBF,machining stents showed reduced degradation rate and increased deposition of calcium phosphate compared to molding stents.Corrosion resistance was improved via paraffin-filling.Consistently,the hemolysis and in vitro osteoblast cell culture models showed favourable biocompatibility in machining stents compared to molding ones,which was improved by paraffin-filling treatment as well.These results implied that the feasibility of the prepared machining stents as the potential in vivo orthopaedic application where slower degradation is required,which could be enhanced by designing canal-filling injection of biomaterials as well.