Polysaccharides from the Green Alga Ulva lactuca Improve Antioxidant Balance and Bone Mineral Density in Diabetic Rats

• 作者: Sahla Belhadj Manel Gargouri Giulia Guerriero Olfa Hentati
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 637-640
• 页数: 4页
• 语种: 英文
• DOI: 10.3967/bes2021.088

摘要

Diabetes mellitus (DM), the 10th? leading cause of death worldwide, is a major and growing public health problem estimated to affect more than 578 million people in 2030 and 700 million people in 2045[1]. In diabetic animals, protein glycation and glucose autoxidation generate free radicals, which cause lipid peroxidation. Therefore, reactive oxygen species (ROS) can quickly accumulate, decrease antioxidant activity, and cause deterioration of kidney and liver function. A disrupted redox balance in cells also damages crucial biomolecules such as deoxyribonucleic acid (DNA), proteins and lipids. Oxidative stress (OS) is elevated in diabetes mellitus and may be a major factor in the development and evolution of the typical long-term pathophysiology of?diabetes?and?its?associated?complications[2].