Non-invasive detection of liver cirrhosis - the "Essen algorithm"

• 作者: Matthias Buechter Guido Gerken
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Letter to Editor
• 页码范围: 1-4
• 页数: 4页
• 语种: 英文
• DOI: 10.20517/2394-5079.2021.99

摘要

The global prevalence of chronic liver disease (CLD) is relatively high and reported to occur in up to 20％ of people[1]. Regarding pathogenesis, chronic inflammation leads to hepatocyte destruction and progressive fibrosis of the liver parenchyma. Cirrhosis is the (mostly irreversible) late-stage of scarring of the liver caused by various forms of CLD. Arising complications due to portal hypertension and/or hepatocellular carcinoma are responsible for the dramatically increasing morbidity and mortality among this patient collective[2,3]. Identification of (advanced) fibrosis is relevant in the course of CLD since it delivers prognostic information and assists in establishing treatment priorities in various clinical conditions. However, liver regeneration is highly efficient and fibrosis potentially reversible whilst a certain "point of no return" is not surpassed. Diagnosis and assessment of the severity of fibrosis is therefore important not only to allow risk stratification but also to deliver adequate therapy to avoid progression of CLD[4-6].