Autophagy in pancreatic cancer

• 作者: Congting Guo Ying Zhao
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（11）
• 所属期刊栏目: Perspective
• 页码范围: 786-790
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab053

摘要

Macroautophagy (hereafter referred to as autophagy) is a conserved eukaryotic process,in which dysfunctional pro-teins,organelles,and other macromole-cules are wrapped in intracellular vesicles called autophagosomes and de-livered to lysosomes for degradation(Mizushima et al.,2008;Mizushima and Komatsu,2011).Autophagy restores cel-lular energy and recycles cytoplasmic precursors,sustaining cell homeostasis and cell survival (Mizushima et al.,2008;Mizushima and Komatsu,2011).Elevated autophagy can be detected in both cancer cells and surrounding stro-mal cells in pancreatic cancer (PC),af-fecting tumor initiation and progression as well (Yang et al.,2011;Endo et al.,2017).The role of autophagy in PC is highly context-dependent.Here,we illus-trate the multifactorial role of autophagy in PC,and the significance of autophagy will be emphasized not only in cancer cells but also in the tumor microenvironment.