Carbene-catalyzed activation of cyclopropylcarbaldehydes for mannich reaction and δ-lactam formation:remote enantioselecitvity control and dynamic kinetic asymmetric transformation

• 作者: Jie Lv Jun Xu Xuling Pan Zhichao Jin Yonggui Robin Chi
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: ARTICLES
• 页码范围: 985-990
• 页数: 6页
• 语种: 英文

摘要

An N-heterocyclic carbene (NHC)-catalyzed enantioselective Mannich reaction of the remote 7-carbon of cyclopro-pylcarbaldehydes is disclosed for the first time.Diastereo-and enantiomerically enriched multicyclic δ-lactam compound is afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asymmetric transformation(DYKAT) processes.Multiple chiral functional molecules can be afforded from the lactam products through simple protocols with retentions of the optical purities.