Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor

• 作者: Honghui Zhang Tailai Chen Keliang Wu Zhenzhen Hou Shigang Zhao Chuanxin Zhang Yuan Gao Ming Gao Zi-Jiang Chen Han Zhao
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 814-817
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Infertility poses a major challenge to human reproductive health,affecting approximately 48 million women worldwide.1 Assisted reproductive techniques (ART),including in vitro fertiliza-tion (IVF) and intracytoplasmic sperm injection (ICSI),enable infertile women to have their biological embryos in vitro and further give birth to babies after embryo transfer.However,about 10％ of all human embryos produced by ART are blocked in the early embryonic stage2 and approximately 2％ fertilized oocytes derived from ART could not accomplish the first cell division.