Catalytic chemodivergent annulations between α-diketones and alkynyl α-diketones

• 作者: Xiangwen Kong Fang Yu Zhizhou Chen Fan Gong Shuang Yang Jinggong Liu Benlong Luo Xinqiang Fang
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: ARTICLES
• 页码范围: 991-998
• 页数: 8页
• 语种: 英文

摘要

Four types of unprecedented and chemodivergent reactions between α-diketones and alkynyl α-diketones have been achieved under the catalysis of phosphine and Brφnsted base,respectively,leading to the rapid construction of four different classes of biologically important but synthetically challenging molecular scaffolds including 2-hydroxyfuran-3(2H)-ones,4-hydroxy-2-oxabicyclo[2.2.1]heptan-3-ones,1,3-diaryl cyclobutanes,and 4-(furan-2(3H)-ylidene)cyclopent-2-enones.The formation of the products includes two novel rearrangement processes,and further transformations on the products can be easily achieved to deliver value-added substances such as highly functionalized cyciopentanes.Moreover,the 2-hydroxyfuran-3(2H)-one products display promising photophysical properties such as green luminescence under UV light and aggregation-induced emission effect,showing the practical application value of this work.The great potential of α-diketones in both synthetic chemistry and material science has been unambiguously demonstrated.