Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis

• 作者: McKay Mullen Fengrui Yang Jun Cao Yang Cao Xu Liu Gee Young Lee Tao Li William Yao Zhihong Yang Jiahai Zhang Kela Johnson Felix Aikhionbare Yong Chen Xinjiao Gao Dongmei Wang Xia Ding Hadiyah-Nicole Green Xing Liu Xuebiao Yao
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（11）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 834-837
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab054

摘要

Dear Editor, The hallmarks of cancer comprise sev-eral distinct biological characteristics ac-quired during the multistep development of human tumors with the unique feature of genomic instability (Shen,2011).These cancer characteristics include sus-taining proliferative signaling,evading growth suppressors,resisting cell death,enabling replicative immortality,inducing angiogenesis,and activating invasion and metastasis (Chen et al.,2011;Song et al.,2018).Triple-negative breast can-cer (TNBC),an aggressive disease with in-creased risks for visceral metastases,has a poor prognosis due to unavailable and viable therapeutic targets (Bianchini et al.,2016).A TNBC diagnosis indicates that cancer cells test negative for three key receptors:estrogen receptor,proges-terone receptor,and human epidermal growth factor receptor 2 (Bianchini et al.,2016).The absence of these three recep-tors renders existing hormone and tar-geted therapies ineffective.