Efficacy and safety of low dose compound betamethasone in the treatment of mild knee osteoarthritis

• 作者: Ye Huang Xiang-Dong Tian Guang-Yu Zhu Rong-Tian Wang Ye-Tong Tan Chang-Xiao Han Han-Dong Chen Tian-Song Ding
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（9）
• 所属期刊栏目: Original article
• 页码范围: 37-41
• 页数: 5页
• 语种: 英文

摘要

Objective: To investigate the efficacy and safety of intra-articular injection of low-dose compound betamethasone in the treatment of mild knee osteoarthritis. Methods: From September 2018 to December 2019, 90 patients with mild knee osteoarthritis were divided into complete dose group and low dose group according to the treatment sequence, 45 cases in each group. The complete dose group was treated with intra-artiular injection of betamethasone(1ml) and sodium hyaluronate(2ml), once a week, three times as a course of treatment. The low dose group was treated with intra-artiular injection of betamethasone(0.3ml) and sodium hyaluronate(2ml), once a week, three times as a course of treatment. Lysholm scores、 the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) were compared between the two groups before and after treatment, and the efficacy and safety of the two groups were evaluated. Results: 80 patients were followed up with an average of (4.96 ± 1.50) months ranging from 3 to 8 months, and 10 cases (11.11％) were dropped out, including 2 cases in the complete dose group, 2 cases in the midway withdrawal group, and 1 case in the treatment course less than the treatment course; 3 cases in the low dose group lost the follow-up, and 2 cases dropped out. Compared with that before treatment, Lysholm scores were significantly improved, WOMAC scores and VAS scores were significantly decreased in the two groups at 3 weeks, 6 weeks and 12 weeks after treatment (P < 0.001). The Lysholm scores of low dose group were78.10 ± 2.16, 86.78 ± 2.55, 80.90 ± 2.26, WOMAC scores were 61.00±1.38, 39.03±1.98, 45.76±1.66 and VAS scores were 2.23±0.89, 0.78±0.73 and 1.05±0.85 in low dose group at 3 weeks, 6 weeks and 12 weeks after treatment. There was no significant difference between the two groups (P > 0.05). No drug-related adverse reactions occurred in both groups. Conclusion: The curative effect of low dose compound betamethasone intra-articular injection in the treatment of mild knee osteoarthritis is equivalent to that of complete dose compound betamethasone. It can improve the function and symptoms of knee joint, and is safe and effective.