Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients

• 作者: Yueyi Deng Qingqing Wu Wanjia Chen Li Zhu Wangyi Liu Fangying Xia Liang Sun Xu Lin Rong Zeng
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Articles
• 页码范围: 565-575
• 页数: 11页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab040

摘要

IgA nephropathy (IgAN) is a leading cause of chronic kidney disease (CKD),which are commonly accompanied by dyslipidemia.Obesity is also associated with dyslipidemia and risk of CKD,but the relation of the dyslipidemia patterns with obesity and dis-ease progression in IgAN patients remains unknown.Traditional Chinese medicine (TCM) and the combined treatment with corti-costeroids and TCM have been shown to be of benefit for IgAN patients,but predictive markers for guiding these treatments are lacking.Here,we quantified 545 lipid species in the plasma from 196 participants,including 140 IgAN patients and 56 healthy volunteers,and revealed an altered plasma lipidome in IgAN patients as compared to healthy participants.Association analysis showed that a subgroup of glycerides,particularly triacylglycerols (TGs) containing docosahexaenoic acid,were positively asso-ciated with high body mass index (BMI) in under-or normal-weight IgAN patients,while several free fatty acids and sphingomye-lins were positively associated with high BMI in overweight or obese IgAN patients.Further,our study suggested that elevated levels of eight lipids,mainly TG species containing linolenic acid,were independent risk factors for IgAN progression and also reported the prospective association of circulating lipids with treatment outcomes in IgAN.Taken together,our findings may not only help to achieve precision medicine but also provide a knowledge base for dietary intervention in the treatment of IgAN.