In vivo laxative,anti-diarrheal,hepatoprotective and diuretic inves-tigations of Sterculia diversifolia and its isolated compounds

• 作者: Fazle Rabbi Amir Zada Amna Nisar Muhammad Sohail Saifullah Khan Khalil Abid Ali Ahmad
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Research Articles
• 页码范围: 717-724
• 页数: 8页
• 语种: 英文
• DOI: 10.19852/j.cnki.jtcm.20210209.001

摘要

OBJECTIVE:To investigated the laxative,anti-diar-rheal,hepatoprotective and diuretic activity of Ster-culia diversifolia and its isolated compounds.METHODS:The laxative activity was studied by counting wet stools while anti-diarrheal activity was performed by measuring gastrointestinal tract motility.Hepatoprotective activity was studied by biochemical and histo-pathological analysis while diuretic activity was performed by urine collection protocol.RESULTS:Doses of 30 and 100 mg/kg of crude methanolic extract of Sterculia diversifolia (MESD)stem bark and leaves,significantly (P ＜ 0.05,P ＜0.01) produced wet feces in subjects pretreated with atropine while 8-hydroxyquercetin and dihy-droquercetin showed highly significant (P ＜ 0.001)results by increasing fecal weight and water con-tents without producing diarrhea.MESD stem bark and leaves also dose-dependently lowered diar-rhea while 8-hydroxyquercetin and dihydroquerce-tin showed highly significant (P ＜ 0.001) results by producing shaped stools in mice.MESD,8-hydroxy-quercetin and dihydroquercetin offered significant protection against histopathological changes in the liver.Diuretic activity of Crude MESD stem bark and leaves extracts shows highly significant diuret-ic effect while dihydroquercetin showed better re-sults than 8-hydroxyquercetin.CONCLUSION:It is concluded that Sterculia diversi-folia and its isolated compounds bears laxative,an-ti-diarrheal,hepatoprotective and diuretic effects.