Recent Advancements in Nanomedicine for'Cold'Tumor Immunotherapy

• 作者: Qinjun Chen Tao Sun Chen Jiang
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2021,（6）
• 页码范围: 143-189
• 页数: 47页
• 语种: 英文

摘要

Although current anticancer immunotherapies using immune check-point inhibitors(ICIs)have been reported with a high clinical success rate,numerous patients still bear'cold'tumors with insuf-ficient T cell infiltration and low immuno-genicity,responding poorly to ICI therapy.Considering the advancements in precision medicine,in-depth mechanism studies on the tumor immune microenvironment(TIME)among cold tumors are required to improve the treatment for these patients.Nanomedicine has emerged as a promising drug delivery system in anticancer immu-notherapy,activates immune function,modulates the TIME,and has been applied in combination with other anticancer therapeutic strategies.This review initially summarizes the mechanisms underlying immunosup-pressive TIME in cold tumors and addresses the recent advancements in nanotechnology for cold TIME reversal-based therapies,as well as a brief talk about the feasibility of clinical translation.