Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution-Isomerization of α-Cyanohydrin Methanesulfonates

• 作者: Shiwen Liu Lingling Meng Xiaojun Zeng Gerald B.Hammond Bo Xu
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Concise Reports
• 页码范围: 913-917
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000579

摘要

We have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution-isomerization of α-cyanohydrin methanesulfonates with alkenylboronic acids.This transition metal-free protocol works under simple and mild condi-tions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance.