Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion

• 作者: Pooyan Makvandi Melissa Kirkby Aaron R.J.Hutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2021,（6）
• 页码范围: 190-230
• 页数: 41页
• 语种: 英文

摘要

Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(～10 to 20 μm),without rupturing or bending during penetration.This ensures that the cargo is released at the predetermined place and time.Therefore,the ability of MN patches to sufficiently pierce the skin is a crucial requirement.In the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared.This is fol-lowed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice.Factors that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research.