The dityrosine crosslink plays a vital role in improving mechanical property and stability of polymers,which has been found in most insects.It has also been exploited in new synthetic materials.Therein,the photochemical method provides a path for the formation of dityrosine bonding and shows its unique superiority.Here,we review different photo-innitiation approaches that generate the dityrosine link.This review may offer new strategies for photo-activated tyrosine unit manipulation.