Modeling cells spreading,motility,and receptors dynamics:a general framework

• 作者: Mattia Serpelloni Matteo Arricca Claudia Bonanno Alberto Salvadori
• 来源期刊: 力学学报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: BIOMECHANICS
• 页码范围: 1013-1030
• 页数: 18页
• 语种: 英文

摘要

The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different time-scales.For this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for "rheology" or "mechanical response".Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible way.Aware of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.