Mechanism of cuscuta-medlar treating male infertility based on network pharmacological method

• 作者: Qi Zhao Ji-Sheng Wang Heng-Heng Dai Zi-Long Chen Jun-Long Feng Fei Yan Hai-Song Li
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Original article
• 页码范围: 36-41
• 页数: 6页
• 语种: 英文

摘要

Objective: To predict couplet medicinals Cuscuta-Medlar(CM) in treat male infertility and analyze their potential mechanisms by the network pharmacology method. Method: TCMSP, BATMAN and literature were used to obtain components of CM, and male infertility targets were predicted by OMIM and GeneCards databases. Cytoscape software was used to construct the "component-target-disease" network. The STRING web site was used for the analysis of Protein-to-protein interaction (PPI) data between compounds and disease. DAVID 6.8 was carried on GO analysis and KEGG pathway analysis. Result: A total of 52 active ingredients and 242 potential targets of CM were obtained, with 7661 male infertility related genes retrieved from disease database. Then 113 common targets were obtained. Biological processes were related to enzyme binding, signaling receptor binding and molecular function regulator. The biological pathways mainly included TNF signaling pathway, apoptosis-related signaling pathway, PI3K/AKT signaling pathway, FoxO signaling pathway, Thyroid hormone signaling pathway and toll-like receptor signaling pathway. Conclusion: CM may treat male infertility by inhibiting inflammation, inhibiting apoptosis and promoting spermatogenesis.