Nanophotonics enhanced coverslip for phase imaging in biology

• 作者: Lukas Wesemann Jon Rickett Jingchao Song Jieqiong Lou Elizabeth Hinde Timothy J.Davis Ann Roberts
• 来源期刊: 光：科学与应用（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Letters
• 页码范围: 957-962
• 页数: 6页
• 语种: 英文

摘要

The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experimentally demonstrate a novel nanostructured coverslip that converts phase information to high-contrast intensity images. This compact device enables real-time, all-optical generation of pseudo three-dimensional images of phase objects on transmission. We show that by placing unstained human cancer cells on the device, the internal structure within the cells can be clearly seen. Our research demonstrates the significant potential of nanophotonic devices for integration into compact imaging and medical diagnostic devices.