Modular Click Chemistry Library:Searching for Better Functions

• 作者: Jiong Zhang Jiajia Dong
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Emerging Topic
• 页码范围: 1025-1027
• 页数: 3页
• 语种: 英文
• DOI: 10.1002/cjoc.202000596

摘要

High throughput screening towards chemical libraries is the primary way to discover lead compounds in developing innovative drugs,especially new molecular entities.Accordingly,the preparation of chemical libraries is the key step for drug development.Now,con-ventional small molecule chemical libraries and DNA-encoded chemical libraries are the main models of chemical libraries for high-throughput screening.Recently,a new model of chemical library,called modular click chemistry library,was proposed,which gives us an alternative choice to construct chemical libraries for high throughput screening and exhibits broad prospects to accelerate drug development.Herein,this article mainly focuses on the strategy to prepare the modular click chemistry library.