Functional micro/nanobubbles for ultrasound medicine and visualizable guidance

• 作者: Chen Zhang Yihong Li Xinyong Ma Wenxin He Chenxi Liu Zhe Liu
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: REVIEWS
• 页码范围: 899-914
• 页数: 16页
• 语种: 英文

摘要

Chemically functionalized gas-filled bubbles with a versatile micro/nano-sized scale have witnessed a long history of devel-opments and emerging applications in disease diagnosis and treatments.In combination with ultrasound and image-guidance,micro/nanobubbles have been endowed with the capabilities of biomedical imaging,drug delivery,gene transfection and disease-oriented therapy.As an external stimulus,ultrasound (US)-mediated targeting treatments have been achieving unprecedented efficiency.Nowadays,US is playing a crucial role in visualizing biological/pathological changes in lives as a reliable imaging technique and a powerful therapeutic tool.This review retrospects the history of ultrasound,the chemistry of functionalized agents and summarizes recent advancements of functional micro/nanobubbles as US contrast agents in preclinical and trans-clinical research.Latest ultrasound-based treatment modalities in association with functional micro/nanobubbles have been highlighted as their great potentials for disease precision therapy.It is believed that these state-of-the-art micro/nanobubbles will become a booster for ultrasound medicine and visualizableguidance to serve future human healthcare in a more comprehensive and practical manner.