For a long time,patients with disorders of consciousness(DoCs)have been considered to have a universally poor prognosis.However,along with the development of rehabilitation and nursing technology,the findings from recent clinical studies herald a philosophical shift:some DoC patients may have a better outcome than originally thought.A recent review suggests that>40%of DoC patients have the potential to achieve an improvement of consciousness level after specific follow-up[1].Unfortu-nately,there is still no effective method to determine the prognosis of DoC patients early.In the clinic,the prognosis for DoC remains restricted to symptom-based behavioral observations.Physicians and scientists have therefore been seeking accurate and objective biomarkers.