Advances in aptamer-based nanomaterials for separation and analysis of non-genetic biomarkers in biofluids

• 作者: Zidan Wang Chuwen Huang Nianrong Sun Chunhui Deng
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: REVIEWS
• 页码范围: 932-947
• 页数: 16页
• 语种: 英文

摘要

Body fluids contain a large number of disease markers including proteins,exosomes and cells,the concentration of which indicates the health status of a body system and can be hence applied to predict the degree of seriousness of a disease.However,the content of disease markers is relatively low.For solving this problem,a variety of pretreatment methods have been developed,among which aptamer-based nanomaterials hold great potential for biomarker capture because of various natural properties of nano-substrates such as high specific surface area,as well as the high affinity of aptamer towards target and the higher stability than antibody.In this review,we summarized the recent aptamer-based nanomaterials for the separation and analysis of different biomarkers including proteins,exosomes and cells.More specifically,the standard of classification de-scription was based on the applied substrates including magnetic substrates and non-magnetic substrates.Moreover,the per-spective of aptamer-based nanomaterials was discussed.