Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Axially Chiral Compounds

• 作者: Bing-Chao Da Shao-Hua Xiang Shaoyu Li Bin Tan
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Chemistry Authors Up Close
• 页码范围: 1787-1796
• 页数: 10页
• 语种: 英文
• DOI: 10.1002/cjoc.202000751

摘要

The well-defined conformational properties of axially chiral com-pounds bring extraordinary values to an assortment of bioactive mol-ecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric transformations.The demonstrated usefulness and un-tapped potential of axially chiral structural motifs stimulate increasing efforts to develop novel and efficient approaches for their preparation.In this regard,the chiral phosphoric acids broadly used in asymmetric Brφnsted acid catalysis have shown high relevance for atroposelective synthesis as well.Our strong interest in reaction chemistry of atro-pisomers has established a rewarding research programme in our group.The course of studies will be recounted in this Account,with discussion focused on the use of chiral phosphoric acids to catalyze construction of several key axially chiral structures such as BINAM,BINOL,NOBIN,arylquinones,SPINOL,arylpyrrole analogues and axially chiral alkenes.