Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

• 作者: Bao Chen Xia-Juan Huan Ze-Hong Miao Nicole J.de Voogd Yu-Cheng Gu Chang-Yun Wang Yue-Wei Guo Xu-Wen Li
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Concise Reports
• 页码范围: 1838-1842
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202100091

摘要

Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A (1) and B (2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin (3) and three known xestospongins (4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.The structures of new compounds were unambiguously determined by extensive spectroscopic and single-crystal X-ray analyses.In bioassay,compounds 4-6 exhibited moderate cytotoxicity against several human cancer cells.