Brain Energy Improvement as an Emerging Approach for Alzheimer's Disease Treatment

• 作者: Xiaoli Pan Shaoming Sang Chunjiu Zhong
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Research Highlights
• 页码范围: 892-893
• 页数: 2页
• 语种: 英文

摘要

Alzheimer's disease (AD),the most common type of dementia,is a devastating neurodegenerative disorder that seriously afflicts millions of patients and their families due to the lack of effective therapeutic drugs and methods. Elucidating the pathogenesis of this disease has always been a great challenge because AD is complicated with multiple pathophysiological features,including neurode-generation characterized by progressive synaptic/neuronal loss leading to brain atrophy,brain Aβ deposition forming plaques,Tau hyperphosphorylation constituting neurofib-rillary tangles,glial activation and neuroinflammation,andglucose hypometabolism.