A molecule,according to Merriam-Webster,is 'the smallest par-ticle of a substance that retains all the properties of the sub-stance'.This definition laid the foundation for molecular sci-ence.Against this reductionist epistemology,holism argues that the whole (e.g.a substance) contains properties that cannot be discovered or understood through the analysis of its parts (e.g.molecules).Aggregation-induced emission (AIE) is an archety-pal example of such holism philosophy.A single molecule of AIE luminogen (AIEgen) does not luminesce but its aggregate can emit efficiently upon excitation.AIE studyblazed a trail towards aggregate science at higher structural hierarchy and greater sys-tem complexity.