Leveraging immunochemotherapy for treating pancreatic cancer

• 作者: Anushka Dongre Robert A.Weinberg
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 1228-1229
• 页数: 2页
• 语种: 英文

摘要

The refractory response of pancreatic ductal adenocarcinoma(PDAC) to multiple treatment regimens can be attributed to the presence of a desmoplastic stroma together with an immunosuppressive tumor microenvironment.In a recent study published in Cell,Koikawa et al.demonstrate that targeting the proline isomerase,Pin1,potentiates the efficacy of immunochemotherapy and enhances the susceptibility of highly resistant PDAC to the anti-tumor immune response.