Efficacy and safety of Xuebijing injection in the treatment of vascular endothelial injury in sepsis patients: A meta-analysis

• 作者: Jia-Wen Zhang Yuan-Li He Yang Shi Meng Li
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: Original article
• 页码范围: 20-25
• 页数: 6页
• 语种: 英文

摘要

Objective: To systematically evaluate the efficacy and safety of Xuebijing injection in the treatment of vascular endothelial injury in sepsis, and to provide evidence-based reference for clinical medication. Methods: The randomized controlled trials of Xuebijing injection combined with conventional treatment (experimental group) versus conventional treatment (control group) for sepsis were collected by computer search of Chinese CNKI database, WANFANG database, and VIP database. Literature screening was performed according to the inclusion and exclusion criteria. According to the Cochrane International Collaboration Evaluator Workbook procedure, the quality evaluation and bias analysis were performed for the literatures included in the meta-analysis. Revman 5.3 software was used for systematic meta-analysis. Results: A total of 15 clinical randomized controlled trials with a total of 930 patients were included. Meta-analysis showed that Xuebijing injection combined with conventional therapy could reduce 28-day mortality in sepsis[OR=0.52,95％CI(0.38,0.71),P<0.0001], APACHE Ⅱ integral [WMD=-2.65,95％CI(-3.23, -2.08),P<0.00001]; be effective in decreasing D-dimer [WMD=-0.79,95％CI(-1.17,-0.40),P<0.0001], TNF-α[WMD=-36.71,95％CI(-43.04,-30.39),P<0.00001], vWF[WMD=-15.94,95％CI(-27.60,-4.28),P=0.007],sE-selectin[WMD=-118.30,95％CI(-139.65,-96.95),P<0.00001], ESM-1[WMD=-135.44,95％CI(-186.30,-84.57),P<0.00001], sTM[WMD=-56.46,95％CI(-66.39,-46.53),P<0.00001]; can effectively increase platelets [WMD=30.78,95％CI(25.65, 35.92),P<0.00001]. Conclusion: Xuebijing injection can not only effectively reduce the release of inflammatory factors, thereby improving vascular endothelial injury, reducing coagulation disorders and blocking coagulation-inflammation network; it can also increase the level of platelets, thereby repairing injured vascular endothelial cells, which has a certain value to reduce the condition of sepsis and improve the prognosis. It also provides some basis for the treatment of sepsis secondary to novel coronavirus pneumonia.