Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

• 作者: Ho Byoung Chae Min Gab Kim Chang Ho Kang Joung Hun Park Eun Seon Lee Sang-Uk Lee Yong Hun Chi Seol Ki Paeng Su Bin Bae Seong Dong Wi Byung-Wook Yun Woe-Yeon Kim Dae-Jin Yun David Mackey Sang Yeol Lee
• 来源期刊: 分子植物（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Research Articles
• 页码范围: 1312-1327
• 页数: 16页
• 语种: 英文

摘要

Reactive oxygen signaling regulates numerous biological processes,including stress responses in plants.Redox sensors transduce reactive oxygen signals into cellular responses.Here,we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog(QSOX1)is a redox sensor that negatively reg-ulates plant immunity against a bacterial pathogen.The expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species(ROS)accumulation.Interestingly,QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase,which,consistent with previous findings,influences reactive nitrogen-mediated regulation of ROS generation.Collectively,our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production.