Visualization of Mitochondrial Membrane Dynamics in Primary Cultured Neurons by Cryo-electron Tomography

• 作者: WANG Pei TIAN Bu-Yun FENG Feng-Ping LUAN Hui-Qin XU Xiao-Jun JI Wei XUE Yan-Hong
• 来源期刊: 生物化学与生物物理进展
• 年，卷（期）: 2021,（11）
• 所属期刊栏目: Letter to Editor
• 页码范围: 1365-1368
• 页数: 4页
• 语种: 中文
• DOI: 10.16476/j.pibb.2021.0302

摘要

Dear Editor, Mitochondria acts as a cellular organelle that produces ATP and buffers Ca2+,and plays an important role in neuronal growth,survival and function[1].Loss of mitochondria will make the ATP supply insufficient,resulting in synaptic transmission dysfunction[2].Further,presynaptic mitochondrial dysfunctions are often associated with severe neurological diseases[3].Abnormal mitochondrial function can also lead to neurodegenerative diseases because of the degeneration of synapse transmission,such as Alzheimer's disease[4]and Parkinson's disease[5].In neurons,mitochondria have a wide range of size,shape and number,which can be constantly changed through fission and fusion events to form a highly dynamic and organized network[6]and also a way of mitochondrial quality control.