Phosphinic Acid/Nal Mediated Reductive Cyclization Approach for Accessing the L-1-Deoxynojirimycin Using a Two-Component Three-Centered(2C3C)Ugi Type Reaction

• 作者: Chandra S Azad Pratibha Shukla Mark A Olson Anudeep K Narula
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Concise Reports
• 页码范围: 1503-1510
• 页数: 8页
• 语种: 英文
• DOI: 10.1002/cjoc.202000634

摘要

Main observation and conclusion A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron approach.This new and quite mild catalytic system,comprised of phenylphosphinic acid/Nal,was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.