Rhodium(Ⅱ)-Catalyzed [4+3] Cyclization of Triazoles with Indole Derivatives and Its Application in the Total Synthesis of(±)-Aurantioclavine

• 作者: Shengguo Duan Bing Xue Hui Meng Zihang Ye Ze-Feng Xu Chuan-Ying Li
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Concise Reports
• 页码范围: 1145-1152
• 页数: 8页
• 语种: 英文
• DOI: 10.1002/cjoc.202000657

摘要

Main observation and conclusion An efficient rhodium(Ⅱ)-catalyzed [4+3] cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed.Azepino[5,4,3-cd]indoles,which are widely distributed in ergot alkaloids with various biological activities,could be obtained in good to excellent yields.In addition,the total synthesis of (±)-aurantioclavine was completed in four steps from the known compound 1a adopting this[4+3] cyclization as a key step.