Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701

• 作者: Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Concise Reports
• 页码范围: 1188-1192
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000736

摘要

Main observation and conclusion Four new chlorinated carbazole alkaloids,chlocarbazomycins (CCBs) A-D,were isolated from sponge associated bacterium Strepto-myces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques (including HRESIMS,1D & 2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the N-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical C1 para-alkyl and C2 meta-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microor-ganisms including methicillin-resistant Staphylococcus aureus (MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida al-bicans.