Cobalt-Catalyzed C-H Allylation of Arenes with Allylic Amines

• 作者: Rui Yan Hang Yu Zhong-Xia Wang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Concise Reports
• 页码范围: 1205-1210
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000680

摘要

Main observation and conclusion [Cp*Co(CO)l2] effectively catalyzes pyridyl-directed C-H allylation of arenes with allylic amines in the presence of AgOAc and CF3COOAg.The reaction features ortho-position monoallylation of 2-pyridylarenes,giving the allylated arenes in moderate to high yields.A range of functional groups including OMe,Me,Ph,F,Cl,Br,CF3,C(O)Me,COOEt,and COOH groups are tolerated.Pyrim-idyl-directed C-H allylation of arenes were also performed under the same conditions.Reaction of 2-phenylpyrimidine,2-(4-methoxyphenyl)pyrimidine,and 2-(3-fluorophenyl)pyrimidine leads to a mixture of ortho-position mono-and bisallylation prod-ucts.Reaction of other 2-(substituted aryl)pyrimidines resulted in ortho-position monoallylation products.