Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform

• 作者: Xiang Ling Zhaokui Jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: RESEARCH ARTICLES
• 页码范围: 142-153
• 页数: 12页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa156

摘要

Photothermal nanotheranostics,especially in the near infrared Ⅱ (NIR-Ⅱ) region,exhibits a great potential in precision and personalized medicine,owing to high tissue penetration of NIR-Ⅱ light.NIR-Ⅱ-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far.Te nanomaterials possess high absorbance to NIR-Ⅱ light but also exhibit high cytotoxicity,impeding their biomedical applications.In this work,the controllable incorporation ofbiocompatible Se into the lattice ofTe nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility,developing TeSex nano-alloys as a new kind of theranostic nanoplatform.We have uncovered that the cytotoxicity ofTe nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy,and can be eliminated by incorporating a moderate proportion ofSe (x =0.43).We have also discovered that the as-prepared TeSex nano-alloys have extraordinarily high NIR-Ⅱ-photothermal conversion efficiency(77.2％),64Cu coordination and computed tomography contrast capabilities,enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-Ⅱ-photothermal therapy of cancer.The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions.